Fig. 3
Remarkable correlation between fecal SCFAs and the levels of GPR43 and NLRP3 mRNA in leukocytes. A Stack bar plot depicted the relative abundance (log 10) of fecal SCFAs, including acetic acid, propionic acid, butyric acid, isobutyric acid, isovaleric acid, valeric acid and caproic acid. B Heatmap presented the correlation between fecal SCFAs and the network presented the correlation between leukocyte GPR43 and NLRP3 mRNA and fecal SCFAs, respectively. Total SCFAs: acetic acid, propionic acid, butyric acid, isobutyric acid, isovaleric acid, valeric acid and caproic acid; SCFAs: acetic acid, propionic acid and butyric acid. Spearman’s correlation analysis; Red, positive correlation; green, negative correlation; red line, positive correlation; blue line, negative correlation; line width, the Spearman correlation coefficient; *P < 0.05; **P < 0.01. C, D Scatter plots of correlation between acetic acid and the levels of GPR43 (R = 0.34, P = 0.046) and NLRP3 (R = − 0.34, P = 0.049) mRNA in leukocytes. E Significantly negative correlation between GPR43 and NLRP3 mRNA expression in leukocytes (R = − 0.33, P = 0.024). Spearman’s correlation analysis