In vitro/in vivo | Models | Cells/animals | O-GlcNAc levels in stress | O-GlcNAc protection | Methods of modulation | References |
---|---|---|---|---|---|---|
In vitro | OGD/R | Primary neuron cultures, Primary astrocyte cultures, HT22 cells | Increase | Increase | P, G | |
LPS | BV2 microglia cells | Increase | Increase | M, P | ||
Aβ | Primary cortical neurons , CHO cells | Decrease | Increase | P | [128] | |
Glutamate | PC12 cells | Increase | Increase | P, G | [129] | |
In vivo | Transient global ischaemia, tMCAO, pMCAO | Mice, Rat | Young: increase Aged: no change | Increase | M, P, G | |
CA/CPR | Mice | Young: increase Aged: no change | Increase | M, P | ||
Hypoxia | Mice | N/A | Increase | P | [137] | |
RH | Zebrafish | Decrease | Increase | M | [138] | |
SAH | Mice | N/A | Increase | P | [126] |