From: Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen
Protein | UniProt ID | PDB ID | AlphaFold ID | Drugs | Compound CID | Drug group | Affinity (kcal/mol) | References |
---|---|---|---|---|---|---|---|---|
ACSL1 | P33121 | P33121 | Adenosine phosphate | 6083 | Approved, investigational, nutraceutical | − 5.71 | ||
ACSBG2 | Q5FVE4 | Q5FVE4 | Oxidized Photinus luciferin | 135398698 | Experimental | − 6.15 | [70] | |
ACAA2 | P42765 | 4c2k | Trimetazidine | 21109 | Experimental | − 4.44 | [71] | |
FABP3 | P05413 | 5hz9 | Oleic acid | 445639 | Approved, Investigational, Vet_approved | − 4.47 | [72] | |
Palmitic acid | 985 | Approved | − 3.86 | [73] | ||||
ALDH5A1 | P51649 | 2w8n | Succinic acid | 1110 | Approved, Nutraceutical | − 3.54 | ||
Valproic acid | 3121 | Approved, Investigational | − 3.08 | [76] | ||||
FFAR4 | Q5NUL3 | Q5NUL3 | BMS-488043 | 507806 | Investigational | − 6.10 | [77] |