| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 |
---|---|---|---|---|---|
Cardiovascular disease | |||||
 Tertile 1 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
 Tertile 2 | 1.34 (1.11–1.61) | 1.25 (1.04–1.51) | 1.25 (1.04–1.51) | 1.27 (1.05–1.53) | 1.14 (0.93–1.38) |
 Tertile 3 | 1.91 (1.60–2.27) | 1.73 (1.46–2.07) | 1.71 (1.44–2.04) | 1.70 (1.42–2.02) | 1.48 (1.22–1.79) |
 P for trend†|  < 0.001 |  < 0.001 |  < 0.001 |  < 0.001 |  < 0.001 |
Myocardial infarction | |||||
 Tertile 1 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
 Tertile 2 | 1.62 (1.03–2.54) | 1.55 (0.98–2.43) | 1.53 (0.97–2.40) | 1.58 (1.01–2.48) | 1.45 (0.91–2.32) |
 Tertile 3 | 2.64 (1.75–3.99) | 2.46 (1.63–3.72) | 2.45 (1.62–3.71) | 2.52 (1.66–3.82) | 2.24 (1.42–3.52) |
 P for trend†|  < 0.001 |  < 0.001 |  < 0.001 |  < 0.001 |  < 0.001 |
Stroke | |||||
 Tertile 1 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
 Tertile 2 | 1.14 (0.75–1.72) | 1.04 (0.69–1.58) | 1.04 (0.69–1.57) | 1.06 (0.70–1.61) | 0.99 (0.64–1.53) |
 Tertile 3 | 1.83 (1.26–2.64) | 1.63 (1.12–2.36) | 1.55 (1.07–2.25) | 1.55 (1.07–2.26) | 1.45 (0.96–2.19) |
 P for trend†| 0.001 | 0.005 | 0.011 | 0.012 | 0.042 |
Unstable angina | |||||
 Tertile 1 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
 Tertile 2 | 1.35 (1.03–1.77) | 1.27 (0.69–1.67) | 1.27 (0.97–1.67) | 1.25 (0.95–1.64) | 1.07 (0.81–1.43) |
 Tertile 3 | 1.79 (1.39–2.31) | 1.62 (1.26–2.09) | 1.61 (1.25–2.08) | 1.55 (1.19–2.00) | 1.28 (0.96–1.69) |
 P for trend†|  < 0.001 |  < 0.001 |  < 0.001 | 0.001 | 0.062 |