Fig. 4From: Downregulation of salusins alleviates hypertrophic cardiomyopathy via attenuating oxidative stress and autophagyAlleviation of oxidative stress by TOR2A downregulation. The increases of ROS (a) and MDA (b) in the heart of rats infused with Ang II were inhibited by TOR2A downregulation. c The decreased SOD activity in the heart of rats infused with Ang II was reversed after TOR2A downregulation. d, e The increase of ROS production in the heart of rats infused with Ang II was suppressed by TOR2A downregulation. f, g The increase of 8-OHdG positive cells in the heart of rats infused with Ang II was blocked after TOR2A downregulation. Data are expressed as the mean ± SEM. a–c N = 7 in each group. d, g N = 6 in each group. Scale bar: 100 μm. Ang angiotensin, TOR2A torsin family 2 member A, ROS reactive oxygen species, MDA malondialdehyde, SOD superoxide dismutase, 8-OHdG 8-hydroxy-2ʹ-deoxyguanosineBack to article page