Ā | Healthy control (nā=ā25) | BHT (nā=ā25) | MHT (nā=ā25) | P |
---|---|---|---|---|
Gender (male/female) | 19/6 | 21/4 | 24/1 | 0.10 |
Age (years) | 42.48āĀ±ā8.39 | 40.08āĀ±ā10.43 | 36.32āĀ±ā11.67 | 0.12 |
BMI (kg/m2) | 23.07āĀ±ā1.68 | 29.24āĀ±ā4.80c | 26.65āĀ±ā4.40a | <0.01 |
SBP (mmHg) | 118.6āĀ±ā4.7 | 147.5āĀ±ā9.4c | 193.8āĀ±ā19.0a,b | <0.01 |
DBP (mmHg) | 79.88āĀ±ā4.02 | 92.00 (90.00ā100.00)c | 114.36āĀ±ā14.33a,b | <0.01 |
Uric acid | 274.84āĀ±ā59.69 | 503.92āĀ±ā116.81c | 508.56āĀ±ā120.21a | <0.01 |
BUN (mmol/L) | 5.17āĀ±ā1.64 | 7.53āĀ±ā3.10 | 15.52 (12.15ā22.89)a,b | <0.01 |
Scr (Ī¼mol/L) | 59.25āĀ±ā11.37 | 132.00 (103.50ā180.50)c | 390.00 (237.00ā546.50)a,b | <0.01 |
eGFR (mL/min/1.73 m2) | 118.60āĀ±ā22.74 | 57.67āĀ±ā30.06c | 17.00 (8.20ā30.00)a,b | <0.01 |
Elabela (ng/ml) | 6.29āĀ±ā0.94 | 4.73āĀ±ā1.25c | 3.82āĀ±ā1.08a,b | <0.01 |
Histopathological | ||||
Ā TAIF | ā | 1.88āĀ±ā0.78 | 2.63āĀ±ā0.71 | <0.01 |
Ā Intimal fibrosis | ā | 1.00(1.00, 2.00) | 2.00(2.00, 2.00) | <0.01 |
Ā Fibrinoid necrosis, n (%) | ā | 0 | 9 (62.5) | <0.01 |
Ā Myointimal cell proliferation, n (%) | ā | 0 | 22 (91.7) | <0.01 |