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TableĀ 1 Demographic and clinicopathological data of all participants

From: Serum Elabela expression is decreased in hypertensive patients and could be associated with the progression of hypertensive renal damage

Ā 

Healthy control (nā€‰=ā€‰25)

BHT (nā€‰=ā€‰25)

MHT (nā€‰=ā€‰25)

P

Gender (male/female)

19/6

21/4

24/1

0.10

Age (years)

42.48ā€‰Ā±ā€‰8.39

40.08ā€‰Ā±ā€‰10.43

36.32ā€‰Ā±ā€‰11.67

0.12

BMI (kg/m2)

23.07ā€‰Ā±ā€‰1.68

29.24ā€‰Ā±ā€‰4.80c

26.65ā€‰Ā±ā€‰4.40a

<0.01

SBP (mmHg)

118.6ā€‰Ā±ā€‰4.7

147.5ā€‰Ā±ā€‰9.4c

193.8ā€‰Ā±ā€‰19.0a,b

<0.01

DBP (mmHg)

79.88ā€‰Ā±ā€‰4.02

92.00 (90.00ā€“100.00)c

114.36ā€‰Ā±ā€‰14.33a,b

<0.01

Uric acid

274.84ā€‰Ā±ā€‰59.69

503.92ā€‰Ā±ā€‰116.81c

508.56ā€‰Ā±ā€‰120.21a

<0.01

BUN (mmol/L)

5.17ā€‰Ā±ā€‰1.64

7.53ā€‰Ā±ā€‰3.10

15.52 (12.15ā€“22.89)a,b

<0.01

Scr (Ī¼mol/L)

59.25ā€‰Ā±ā€‰11.37

132.00 (103.50ā€“180.50)c

390.00 (237.00ā€“546.50)a,b

<0.01

eGFR (mL/min/1.73 m2)

118.60ā€‰Ā±ā€‰22.74

57.67ā€‰Ā±ā€‰30.06c

17.00 (8.20ā€“30.00)a,b

<0.01

Elabela (ng/ml)

6.29ā€‰Ā±ā€‰0.94

4.73ā€‰Ā±ā€‰1.25c

3.82ā€‰Ā±ā€‰1.08a,b

<0.01

Histopathological

Ā TAIF

ā€“

1.88ā€‰Ā±ā€‰0.78

2.63ā€‰Ā±ā€‰0.71

<0.01

Ā Intimal fibrosis

ā€“

1.00(1.00, 2.00)

2.00(2.00, 2.00)

<0.01

Ā Fibrinoid necrosis, n (%)

ā€“

0

9 (62.5)

<0.01

Ā Myointimal cell proliferation, n (%)

ā€“

0

22 (91.7)

<0.01

  1. SBP systolic blood pressure, DBP diastolic blood pressure, BUN blood urine nitrogen, Scr serum creatinine, eGFR estimated glomerular filtration rate, TAIF tubular atrophy/interstitial fibrosis.
  2. aPā€‰<ā€‰0.05, healthy control vs. MHT group; bPā€‰<ā€‰0.05, BHT group vs. MHT group; cPā€‰<ā€‰0.05, healthy control vs. BHT group