Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study

Table 2 The baseline laboratory indicators before CRRT of patients in the two groups were comparable (per visit)

Variables	Regional citrate group (N_visit1 = 97)	Nafamostat mesylate group (N_visit2 = 75)	p-value
*WBC (10^9/L)	9.4 (7.3, 14.6)	12.9 (6.5, 24.4)	0.033
RBC (10^12/L)	2.5 (2.3, 2.9)	2.5 (2.2, 3.0)	0.808
HB (g/L)	74.0 (65.0, 85.0)	74.0 (64.0, 88.0)	0.581
Hct (%)	22.9 (20.1, 26.4)	22.3 (19.2, 26.9)	0.857
PLT (10^9/L)	136.0 (61.0, 216.0)	86.0 (37.0, 170.0)	0.068
*PT (S)	13.9 (12.9,15.1)	16.5 (14.9, 17.8)	0.000
*INR	1.2 (1.1, 1.3)	1.4 (1.3, 1.6)	0.000
*APTT (S)	31.6 (28.4, 37.0)	41.1 (33.7, 50.7)	0.000
Fib (g/L)	3.4 (2.3, 4.6)	3.2 (2.0, 4.8)	0.794
TT (S)	17.0 (15.9, 18.8)	17.4 (16.0, 19.5)	0.501
DD (ng/mL)	3.4 (2.2, 6.8)	4.3 (2.4, 8.9)	0.256
*Na⁺ (mmol/L)	140.0 (138.0, 145.0)	138.0 (135.0, 141.0)	0.001
K⁺ (mmol/L)	4.1 (3.8, 4.7)	4.3 (3.8, 4.8)	0.615
*BUN (mmol/L)	19.6 (11.7, 28.3)	13.3 (8.6, 21.7)	0.019
*Cr (umol/L)	265.0 (105.0, 503.2)	138.0 (96.0, 235.0)	0.000
BNP (pg/mL)	471.7 (68.6, 1292.3)	294.0 (79.2, 553.0)	0.217
*SOFA	9.0 (6.0, 12.0)	10.0 (8.0, 14.0)	0.001
APACHE II	24.0 (19.0, 27.0)	24.0 (21.5, 26.0)	0.713

The data presented in this table was derived from baseline measurements obtained before each RRT session for 46 patients distributed across two groups (Ntotal visit = 172)
Continuous variables were described by median and interquartile range
“*” means the variable was significantly different between the two groups
Statistics analysis was conducted using the Mann–Whitney U test. The p-value of < 0.05 was considered statistically significant. Calculations were performed using IBM SPSS Statistics for Windows (Version 28.0. Armonk, NY: IBM Corp)
WBC White Blood Cell Count, RBC Red Blood Cell Count, Hb Hemoglobin, HCT Hematocrit, PLT Platelet Count, PT Prothrombin Time, INR International Normalized Ratio, APTT Activated Partial Thromboplastin Time, Fib Fibrinogen, TT Thrombin Time, DD D-dimer, Na + Sodium, K + Potassium, BUN Blood Urea Nitrogen, Cr Creatinine, BNP B-type Natriuretic Peptide, SOFA Sequential Organ Failure Assessment, APACHE II Acute Physiology and Chronic Health Evaluation II, RRT Renal Replacement Therapy

ISSN: 2047-783X