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Table 1 The admission baseline characteristics of patients in both groups were comparable

From: Nafamostat mesylate versus regional citrate anticoagulation for continuous renal replacement therapy in patients at high risk of bleeding: a retrospective single-center study

Variables

Regional citrate group (N = 22)

Nafamostat mesylate group (N = 24)

p-value

Baseline

 Gender (male %)

15 (68.2%)

16 (66.7%)

0.913

 Age (yes.)

65.5 (56.3, 75.3)

71.5 (63.5,77.8)

0.271

 Height (cm)

170 (160.8, 172.5)

170 (163.0, 173.8)

0.825

 Weight (kg)

65 (58.8, 80.5)

60 (50.3, 64.3)

0.063

Infection site

 Respiratory tract

9 (40.9%)

7 (29.2%)

 

 Urinary tract

0 (0.0%)

1 (4.2%)

 

 Abdominal infection

1 (4.5%)

3 (12.5%)

 

 Bloodstream infection

0 (0.0%)

1 (4.2%)

 

 Skin and soft tissue

0 (0.0%)

1 (4.2%)

 

Reasons for high risk of bleeding

 Hemorrhage

  Cerebral hemorrhage

9 (40.9%)

2 (8.3%)

 

  Gastrointestinal hemorrhage

6 (27.3%)

5 (20.8%)

 

  Postoperative hemorrhage

0 (0.0%)

1 (4.2%)

 

  Hemoptysis

1 (4.5%)

1 (4.2%)

 

  Hematuresis

0 (0.0%)

1 (4.2%)

 

  Hemorrhoidal bleeding

1 (4.5%)

1 (4.2%)

 

  Hematoma

0 (0.0%)

1 (4.2%)

 

  Severe thrombocytopenia

3 (13.6%)

5 (20.8%)

 

  Coagulation disorders

2 (9.1%)

5 (20.8%)

 

  Postoperative surgery

0 (0.0%)

2 (8.3%)

 

Underlying diseases

 Hypertension n (%)

14 (63.6%)

12 (50.0%)

0.351

 COPD n (%)

2 (40%)

3 (60%)

0.711

 DM n (%)

14 (60.9%)

9 (39.1%)

0.077

 AKI n (%)

3 (27.3%)

8 (72.7%)

0.118

 *CKD n (%)

15 (68.2%)

7 (31.8%)

0.008

 Cancer n (%)

1 (4.5%)

4 (16.7%)

0.187

 AF n (%)

0

4 (16.7%)

0.450

 HF n (%)

5 (22.7%)

7 (29.2%)

0.619

Coronary heart disease

  

0.307

 CAD n (%)

6 (27.3%)

3 (12.5%)

 

 ACS n (%)

0

1 (4.2%)

 

Cerebrovascular accident

 

0.070

 AIS n (%)

4 (18.2%)

1 (4.2%)

 

 History of CH n (%)

2 (9.1%)

0

 

 History of stroke n (%)

7 (31.8%)

5 (20.8%)

 

Others

  

0.447

 Acute pancreatitis n (%)

1 (4.5%)

0

 

 Liver abscess n (%)

2 (9.1%)

4 (16.7%)

 

Critical interventions and complications

 Sepsis n (%)

10 (45.5%)

13 (54.2%)

0.555

 Shock n (%)

9 (40.9%)

15 (62.5%)

0.143

 MODS n (%)

9 (40.9%)

9 (37.5%)

0.813

 Mechanic ventilation n (%)

19 (86.4%)

18 (75.0%)

0.332

  1. Continuous variables were described by median and interquartile range. Categorical variables were described by counts and percentages, representing the count within each subgroup divided by the total number of observations (N) in that respective subgroup
  2. Statistics analysis was conducted using the Mann–Whitney U test, χ2 test, or Fisher’s exact test. The p-value of < 0.05 was considered statistically significant. Calculations were performed using IBM SPSS Statistics for Windows (Version 28.0. Armonk, NY: IBM Corp)
  3. Yes years, cm centimeters, kg kilograms, COPD Chronic Obstructive Pulmonary Disease, DM Diabetes Mellitus, AKI Acute Kidney Injury, CKD Chronic Kidney Disease, AF Atrial Fibrillation, HF Heart Failure, CAD Coronary Artery Disease, ACS Acute Coronary Syndrome, AIS acute ischemic stroke, CH cerebral hemorrhage, MODS Multiple Organ Dysfunction Syndrome
  4. “*” means the variable was significantly different between the two groups
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European Journal of Medical Research

ISSN: 2047-783X

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