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Table 1 Metabolites change after TFG-β1 challenge

From: Amifostine ameliorates bleomycin-induced murine pulmonary fibrosis via NAD+/SIRT1/AMPK pathway-mediated effects on mitochondrial function and cellular metabolism

Metabolites

Mean Diff (PBS vs TGF-β1)

Adjusted P value

Citrate

0.37

 < 0.0001

cis-Aconitate

0.7733

 < 0.0001

C-isocitrate

1.207

 < 0.0001

D-G6P

− 0.56

 < 0.0001

PEP

− 1.027

 < 0.0001

Pyruvate

− 0.52

 < 0.0001

ATP

1.543

 < 0.0001

AMP

− 0.3067

0.0005

GTP

0.04

0.9532

GMP

− 0.1767

0.0992

Lactate

− 1.543

 < 0.0001

L-Malic acid

− 0.05

0.9137

Furmarate

− 0.19

0.0656

Succinate

− 1.543

 < 0.0001

α-Ketoglutrate

− 0.82

 < 0.0001

Acetyl-CoA

0.65

 < 0.0001

NAD

− 1.62

 < 0.0001

NADP

0.03333

0.9721

NADH

1.71

 < 0.0001

NADPH

0.01333

0.9981

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European Journal of Medical Research

ISSN: 2047-783X

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