Table 4 Univariate log-rank and multivariate analyses for local recurrence-free and metastasis-free survivals in primary localized IHCC
From: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
Parameter | Category | Case No | Local recurrence-free survival | Metastasis-free survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
No. of event | p-value | R.R | 95% C.I | p-value | No. of event | p-value | R.R | 95% C.I | p-value | |||
Gender | Male | 108 | 54 | 0.2170 | – | – | – | 21 | 0.1008 | – | – | – |
Female | 74 | 31 |  | – | – | – | 44 |  | – | – | – | |
Age (years) |  < 65 | 107 | 55 | 0.2993 | – | – | – | 42 | 0.2936 | – | – | – |
 ≥ 65 | 75 | 30 |  | – | – | – | 23 |  | – | – | – | |
Hepatitis | Hepatitis B | 72 | 33 | 0.7333 | – | – | – | 26 | 0.8762 | – | – | – |
Hepatitis C | 29 | 13 |  | – | – | – | 11 |  | – | – | – | |
Non-B, non-C | 81 | 39 |  | – | – | – | 28 |  | – | – | – | |
Intrahepatic lithiasis | Not identified | 102 | 41 | 0.0551 | – | – | – | 31 | 0.1000 | – | – | – |
Present | 80 | 44 |  | – | – | – | 34 |  | – | – | – | |
Surgical margin | R0 | 163 | 71 |  < 0.0001* | 1 | – |  < 0.001* | 54 |  < 0.0001* | 1 |  | 0.014* |
R1 | 19 | 14 |  | 3.428 | 1.764–6.663 |  | 11 |  | 2.467 | 1.202–5.062 |  | |
Primary tumor (T) | T1 | 87 | 28 |  < 0.0001* | 1 | - | 0.015* | 21 |  < 0.0001* | 1 | - | 0.006* |
T2 | 61 | 32 |  | 1.715 | 0.985–2.985 |  | 26 |  | 2.180 | 1.220–3.895 |  | |
T3 | 34 | 25 |  | 2.459 | 1.327–4.559 |  | 18 |  | 2.757 | 1.394–5.454 |  | |
Histological variants | Large duct type | 105 | 58 | 0.0085* | 1 | – | 0.591 | 43 | 0.0759 | – | – | – |
Small duct type | 77 | 27 |  | 0.870 | 0.523–1.446 |  | 22 |  | – | – | – | |
Histological Grade(Differentiation) | Well | 61 | 28 | 0.0299* | 1 | – | 0.627 | 22 | 0.1794 | – | – | – |
Moderately | 66 | 27 |  | 0.960 | 0.551–1.671 |  | 22 |  | – | – | – | |
Poorly | 55 | 30 |  | 1.238 | 0.719–2.132 |  | 21 |  | – | – | – | |
UBE2C Exp | Low expression | 91 | 29 |  < 0.0001* | 1 | – | 0.004* | 24 | 0.0008* | 1 | – | 0.022* |
High expression | 91 | 56 |  | 2.087 | 1.268–3.438 |  | 41 |  | 1.846 | 1.092–3.121 |  | |