Table 3 Univariate log-rank and multivariate analyses for overall and disease-specific survivals in primary localized IHCC
From: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
Parameter | Category | Case No | Overall survival | Disease-specific survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
No. of event | p-value | R.R | 95% C.I | p-value | No. of event | p-value | R.R | 95% C.I | p-value | |||
Gender | Male | 108 | 50 | 0.0254* | 1 | – | 0.105 | 9 | 0.0072* | 1 | – | 0.048* |
Female | 74 | 21 |  | 1.532 | 0.914–2.566 | – | 32 |  | 2.118 | 1.006–4.457 | – | |
Age (years) |  < 65 | 107 | 37 | 0.2626 | – | – | - | 28 | 0.2125 | – | – | – |
 ≥ 65 | 75 | 34 |  | – | – | - | 13 |  | – | – | – | |
Hepatitis | Hepatitis B | 72 | 32 | 0.2379 | – | – | - | 16 | 0.4561 | – | – | – |
Hepatitis C | 29 | 8 |  | – | – | – | 19 |  | – | – | – | |
Non-B, non-C | 81 | 31 |  | – | – | – | 6 |  | – | – | – | |
Intrahepatic lithiasis | Not identified | 102 | 36 | 0.2831 | – | – | – | 19 | 0.1613 | – | – | – |
Present | 80 | 35 |  | – | – | – | 22 |  | – | – | – | |
Surgical margin | R0 | 163 | 59 |  < 0.0001* | 1 | – | 0.004* | 31 |  < 0.0001* | 1 | – |  < 0.001* |
R1 | 19 | 12 |  | 2.756 | 1.389–5.467 |  | 10 |  | 4.523 | 2.020–10.126 |  | |
Primary tumor (T) | T1 | 87 | 25 | 0.0001* | 1 | – | 0.020* | 9 |  < 0.0001* | 1 | – | 0.004* |
T2 | 61 | 27 |  | 1.783 | 1.029–3.089 | – | 19 |  | 3.521 | 1.583–7.830 | – | |
T3 | 34 | 19 |  | 2.371 | 1.242–4.524 | – | 13 |  | 3.735 | 1.519–9.184 | – | |
Histological variants | Large duct type | 105 | 43 | 0.4281 | – | – | – | 27 | 0.1984 | – | – | – |
Small duct type | 77 | 28 |  | – | – | – | 14 |  | – | – | – | |
Histological Grade (Differentiation) | Well | 61 | 20 | 0.1663 | – | – | – | 12 | 0.3881 | – | – | – |
Moderately | 66 | 28 |  | – | – | – | 16 |  | – | – | – | |
Poorly | 55 | 23 |  | – | – | – | 13 |  | – | – | – | |
UBE2C Exp | Low expression | 91 | 28 | 0.0013 | 1 | – | 0.046*- | 13 | 0.0004* | 1 | – | 0.019*- |
High expression | 91 | 43 |  | 1.668 | 1.068–2.758 | – | 28 |  | 2.289 | 1.143–4.583 | – | |