Table 1 Summary of the alterations of gene associated with ubiquitination (GO:0016567) in cholangiocarcinoma (GSE26566)
From: Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma
Probe | CCA vs non-tumor# | CCA vs normal intrahepatic bile duct& | Gene symbol | Molecular function | Biological Process | ||
|---|---|---|---|---|---|---|---|
log ratio | p-value | log ratio | p-value | ||||
ILMN_1714730 | 1.7925 |  < 0.0001 | 1.845 |  < 0.0001 | UBE2C | Ligase activity, ubiquitin-protein ligase activity | Ubiquitin cycle, phosphoinositide-mediated signaling, protein ubiquitination, ubiquitin-dependent protein catabolism, cyclin catabolism, spindle organization and biogenesis, mitosis, cell cycle, cell division |
ILMN_1777881 | 0.8437 | 0.0117 | 0.9321 |  < 0.0001 | TSPAN17 | Ubiquitin-protein ligase activity | Protein ubiquitination |
ILMN_1720241 | 0.6438 | 0.0032 | 0.3769 |  < 0.0001 | TRIP12 | Thyroid hormone receptor binding, ligase activity, ubiquitin-protein ligase activity, binding | Protein ubiquitination |
ILMN_1759436 | 0.5235 | 0.0132 | 0.539 |  < 0.0001 | NOSIP | Ubiquitin-protein ligase activity | Protein ubiquitination |
ILMN_1744647 | 0.503 | 0.0215 | 0.2871 | 0.0001 | CAND1 | Protein binding | Regulation of transcription; DNA-dependent, protein ubiquitination, transcription, negative regulation of enzyme activity |
ILMN_1815475 | 0.3065 | 0.0337 | 0.2021 |  < 0.0001 | BAZ1B | Metal ion binding, zinc ion binding, transcription factor activity, protein binding | Regulation of transcription; DNA-dependent, transcription |
ILMN_1705433 | 0.2181 | 0.0262 | 0.1568 |  < 0.0001 | CBLL1 | Ubiquitin-protein ligase activity, zinc ion binding, metal ion binding, nucleic acid binding, protein binding | Negative regulation of cell adhesion, protein ubiquitination, cell–cell adhesion, positive regulation of endocytosis, positive regulation of cell migration |
ILMN_1702928 | − 0.2834 | 0.0152 | − 0.1773 |  < 0.0001 | FBXO9 | binding, ubiquitin-protein ligase activity | Protein ubiquitination |
ILMN_1686466 | − 0.2404 | 0.0183 | − 0.2333 |  < 0.0001 | FBXO24 | Ubiquitin-protein ligase activity | Protein ubiquitination |
ILMN_1666652 | − 0.2379 | 0.0179 | − 0.3038 |  < 0.0001 | BRCA1 | Metal ion binding, transcription coactivator activity, DNA binding, androgen receptor binding, protein binding, ubiquitin-protein ligase activity, zinc ion binding, tubulin binding | Protein ubiquitination, regulation of apoptosis, cell cycle checkpoint, positive regulation of transcription; DNA-dependent, androgen receptor signaling pathway, cell cycle, regulation of transcription from RNA polymerase II promoter, positive regulation of DNA repair, DNA damage response; signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA damage response; signal transduction resulting in induction of apoptosis, regulation of transcription from RNA polymerase III promoter, negative regulation of centriole replication, regulation of cell proliferation, DNA repair |
ILMN_1652872 | − 0.1735 | 0.0151 | − 0.2157 |  < 0.0001 | UBOX5 | Zinc ion binding, metal ion binding, ubiquitin-protein ligase activity, protein binding | Protein ubiquitination |