Fig. 8

Potential biological functions of co-expression gene modules in laryngeal squamous cell carcinoma single cells. A Soft power threshold selection for single-cell weighted gene co-expression analysis of laryngeal squamous cell carcinoma. B Malignant epithelial cells were subset to conduct high dimensional weighted gene co-expression analysis. C According to the gene function scores, four co-expression gene modules were found relatively laryngeal squamous cell carcinoma (LSCC)-specific. D The biological processes mapped to four gene modules specific to LSCC. E Protein interaction network of M2 gene module and triosephosphate isomerase 1 (TPI1) in LSCC. Triangle refers to the transcription factor and rectangle refers to the common protein. To explore the therapeutic potential of TPI1, cellminer analysis was performed on the genomic and pharmacologic data. Higher expression level of TPI1 could be used to predict higher half maximal inhibitory concentration of gemcitabine and cladribine (F)