Fig. 10

Potential pro-tumor roles of triosephosphate isomerase 1 in laryngeal squamous cell carcinoma single cells. A, B Glycolysis and DNA replication activities were calculated in laryngeal squamous cell carcinoma (LSCC) single cells using AUCell. C, D Analysis revealed a strong positive correlation between the expression levels of triosephosphate isomerase 1 (TPI1) and both glycolysis and DNA replication activities. E Gene fitness effect analysis of TPI1 in LSCC cell lines using clustered regularly interspaced short palindromic repeats (CRISPR) screen. These findings suggest that TPI1 was essential for the survival and proliferation of LSCC cells and elevated TPI1 expression may contribute to enhanced glycolysis and DNA replication processes in LSCC single cells. ^****, p < 0.0001