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Table 3 Unfavorable functional outcome stratified by CHIP carrier status and variant of IL-6R

From: Association between clonal hematopoiesis-related gene mutations and unfavorable functional outcome in patients with large-artery atherosclerotic stroke

 

IL6R p.Asp358Ala

n (%)

No IL6R p.Asp358Ala

n (%)

Unadjusted OR (95%CI)

p value

aAdjusted OR (95%CI)

p value

pinteraction

ALL

 CHIP

10/68 (14.7)

15/42 (35.7)

0.31 (0.12–0.78)

0.01

0.30 (0.12–0.76)

0.01

0.02

 No CHIP

421/2162 (19.5)

225/1124 (20.0)

0.97 (0.81–1.16)

0.71

0.96 (0.80–1.15)

0.68

 

LAA

 CHIP

3/32 (9.28)

11/21 (52.4)

0.09 (0.02–0.41)

0.002

0.10 (0.02–0.42)

0.002

0.001

 No CHIP

253/903 (33.1)

125/500 (25.0)

1.12 (0.87–1.44)

0.37

1.10 (0.85–1.42)

0.46

 

CE

 CHIP

4/10 (40.0)

2/4 (50.0)

0.67 (0.07–6.87)

0.73

0.66 (0.07–6.44)

0.72

0.83

 No CHIP

51/221 (23.1)

26/97 (26.8)

0.82 (0.47–1.42)

0.48

0.85 (0.49–1.47)

0.56

 

SAO

 CHIP

3/26 (11.5)

2/17 (11.8)

0.98 (0.15–6.57)

0.98

0.93 (0.14–6.23)

0.94

0.87

 No CHIP

117/1011 (11.6)

74/527 (14.0)

0.80 (0.59–1.10)

0.16

0.79 (0.58–1.07)

0.13

 
  1. CE cardioembolism, CHIP clonal hematopoiesis of indeterminate potential, LAA large-artery atherosclerosis, OR odds ratio, 95% CI 95% confidence interval, SAO small-artery occlusion
  2. aOdds ratios (ORs) were calculated using a logistic regression model and adjusted by stabilized inverse probability weights (IPTW) with age, gender, sex, BMI, smoking, drinking, and history of disease (i.e., hypertension, diabetes mellitus and hyperlipidemia)
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European Journal of Medical Research

ISSN: 2047-783X

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