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Table 2 Unfavorable functional outcome stratified by CHIP carrier status and hsCRP levels

From: Association between clonal hematopoiesis-related gene mutations and unfavorable functional outcome in patients with large-artery atherosclerotic stroke

 

CHIP, n (%)

No CHIP, n (%)

Unadjusted OR (95%CI)

p value

aAdjusted OR (95%CI)

p value

pinteraction

ALL

 hsCRP > median

18/52 (34.6)

409/1644 (24.9)

1.60 (0.89–2.86)

0.11

1.53 (0.83–2.80)

0.17

0.33

 hsCRP ≤ median

7/58 (12.1)

237/1642 (14.4)

0.81 (0.37–1.81)

0.61

0.95 (0.46–1.98)

0.90

 

LAA

 hsCRP > median

10/21 (47.6)

238/720 (33.1)

1.84 (0.89–2.86)

0.17

2.45 (1.00–5.98)

0.049

0.01

 hsCRP ≤ median

4/32 (12.5)

140/710 (19.7)

0.58 (0.20–1.69)

0.32

0.30 (0.08–1.13)

0.08

 

CE

 hsCRP > median

4/6 (66.7)

54/160 (33.8)

3.93 (0.70–22.12)

0.12

2.29 (0.28–19.02)

0.44

0.49

 hsCRP ≤ median

2/8 (25.0)

23/158 (14.6)

1.96 (0.37–10.29)

0.43

0.78 (0.08–7.43)

0.83

 

SAO

 hsCRP > median

3/24 (12.5)

113/765 (14.8)

0.82 (0.24–2.81)

0.76

0.62 (0.16–2.45)

0.49

0.71

 hsCRP ≤ median

2/19 (10.5)

78/773 (10.1)

1.05 (0.24–4.62)

0.95

0.92 (0.18–4.73)

0.92

 
  1. CE cardioembolism, CHIP clonal hematopoiesis of indeterminate potential, hsCRP high-sensitivity C-reactive protein, LAA large-artery atherosclerosis, OR odds ratio, 95% CI 95% confidence interval, SAO small-artery occlusion
  2. aOdds ratios (ORs) were calculated using a logistic regression model and adjusted by stabilized inverse probability weights (IPTW) with age, gender, sex, BMI, smoking, drinking, and history of disease (i.e., hypertension, diabetes mellitus and hyperlipidemia)
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European Journal of Medical Research

ISSN: 2047-783X

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