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Table 1 Baseline characteristics of the study population stratified by CHIP

From: Association between clonal hematopoiesis-related gene mutations and unfavorable functional outcome in patients with large-artery atherosclerotic stroke

Characteristic

Total (n = 3396)

Non-CHIP (n = 3286)

CHIP (n = 110)

p value

Age (y), median (IQR)

62.0 (54.0–69.0)

62.0 (54.0–69.0)

68.5 (64.0–76.0)

<0.001

Age, n (%)

<0.001

 < 40

71 (2.1)

71 (2.2)

0

 

 40–49

368 (10.8)

364 (11.1)

4 (3.6)

 

 50–59

912 (26.9)

900 (27.4)

12 (10.9)

 

 60–69

1199 (35.3)

1157 (35.2)

42 (38.2)

 

 70–79

682 (20.1)

648 (19.7)

34 (30.9)

 

 ≥ 80

164 (4.8)

146 (4.4)

18 (16.4)

 

Female, n (%)

989 (29.1)

945 (28.8)

44 (40.0)

0.01

BMI (kg/m2), mean ± SD

24.9 ± 3.3

24.9 ± 3.3

24.7 ± 3.5

0.51

Current smoking, n (%)

1165 (34.3)

1142 (34.8)

23 (20.9)

0.003

Drinking, n (%)

594 (17.5)

582 (17.7)

12 (10.9)

0.06

Medical history, n (%)

 IS/TIA

743 (21.9)

717 (21.8)

26 (23.6)

0.65

 CHD

334 (9.8)

322 (9.8)

12 (10.9)

0.70

 Hypertension

2178 (64.1)

2102 (64.0)

76 (69.1)

0.27

 Diabetes mellitus

841 (24.8)

817 (24.9)

24 (21.8)

0.47

 Hypercholesterolemia

277 (8.2)

270 (8.2)

7 (6.4)

0.48

NIHSS

 Median (IQR)

3.0 (1.0–5.0)

3.0 (1.0–5.0)

3.0 (1.0–5.0)

0.80

TOAST

0.23

 LAA

1483 (43.7)

1430 (43.5)

53 (48.2)

 

 CE

332 (9.8)

318 (9.7)

14 (12.7)

 

 SAO

1581 (46.6)

1538 (46.8)

43 (39.1)

 

Laboratory index

 hsCRP

5.6 ± 18.8

5.6 ± 19.1

3.4 ± 5.7

0.53

 HGB

142.2 ± 16.2

142.3 ± 16.2

138.9 ± 15.1

0.01

 WBC

7.1 ± 2.1

7.1 ± 2.1

7.2 ± 2.3

0.70

 MONO

0.4 ± 0.2

0.4 ± 0.2

0.4 ± 0.2

0.53

 NEUT

4.7 ± 2.1

4.7 ± 1.9

5.3 ± 5.6

0.64

 TG

1.6 ± 1.0

1.6 ± 1.0

1.5 ± 0.6

0.59

 LDL

2.5 ± 1.0

2.4 ± 1.0

2.6 ± 1.1

0.21

 HDL

1.0 ± 0.3

1.0 ± 0.3

1.0 ± 0.3

0.09

 CHOL

4.1 ± 1.2

4.1 ± 1.2

4.2 ± 1.2

0.55

 HCY

19.4 ± 12.9

19.4 ± 12.8

20.0 ± 15.5

0.98

Time from symptom onset to arrival at hospital, day(s)

 Median (IQR)

2.0 (1.0–4.0)

2.0 (1.0–4.0)

2.0 (1.0–4.0)

0.81

  1. BMI body mass index, CE cardioembolism, CHD coronary heart disease, CHIP clonal hematopoiesis of indeterminate potential, CHOL total cholesterol, HCY homocysteine, HDL high density lipoprotein, HGB hemoglobin, hsCRP high-sensitivity C-reactive protein, IQR interquartile range, IS ischemic stroke, LAA large-artery atherosclerosis, LDL low-density lipoprotein, MONO monocyte count, NEUT Neutrophil count, NIHSS National Institutes of Health Stroke Scale score, SAO small-artery occlusion, TIA transient ischemic attack, WBC white blood cell count, TG triglyceride
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European Journal of Medical Research

ISSN: 2047-783X

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