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Fig. 5 | European Journal of Medical Research

Fig. 5

From: CHKB-AS1 enhances proliferation and resistance to NVP-BEZ235 of renal cancer cells via regulating the phosphorylation of MAP4 and PI3K/AKT/mTOR signaling

Fig. 5

CHKB-AS1 downregulated the phosphorylation of MAP4 to promote drug resistance. A, B CHKB-AS1 bound to MAP4 in the N-terminal domain. C, D Western blot showed that CHKB-AS1 prevented MAP4 from being phosphorylated in parental and resistant cells. E Phosphorylation of MAP4 might be responsible for the inhibition effect of MAP4 brought by the knockdown of CHKB-AS1. F, G CCK8 assay showed that CHKB-AS1 up-regulated MAP4 insensitized cells to NVP-BEZ235

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European Journal of Medical Research

ISSN: 2047-783X

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