Table 2 Studies related to nanoparticle-loaded MSCs-Exo for targeted therapy
From: Mesenchymal stem cells-derived exosomes: novel carriers for nanoparticle to combat cancer
Cell type | Nanoparticles | Disease | Loading method | Results | References |
|---|---|---|---|---|---|
MSCs | Gold nanoparticles (GNPs) | Brain injury | Glucose enters cells through an energy-dependent process that is facilitated by a specific protein called GLUT-1 | Significant accumulation of labeled exosomes at the site of brain injury within 24Â h | [54] |
MSCs | Gold nanoparticles (GNPs) | Various brain disorders | Glucose enters cells through an energy-dependent process that is facilitated by a specific protein called GLUT-1 | Promising diagnostic tool for brain disorders- Potential for enhancing neuronal recovery | [57] |
Human MSCs, A431 squamous cell line | GNPs | Cancer | Glucose enters cells through an energy-dependent process that is facilitated by a specific protein called GLUT-1 | Enhanced capabilities of MSCs-Exo for tumor-targeted therapy | [58] |
MSCs | Cobalt sulfide quantum dots (CoS QDs) | Bladder cancer | Electrotransfection | These exosomes specifically induced the increase of reactive oxygen species (ROS) concentration in bladder cancer cells | [59] |
MSCs | Superparamagnetic iron oxide nanoparticles (SPIONs), curcumin | Glioma | Click chemistry | –Effective crossing of the blood–brain barrier- Positive outcomes in targeted imaging and glioma therapy | [59] |