Systemic immune-inflammation index (SII) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in the general population

Table 3 Threshold effect analysis of SII on mortality using the two-piecewise regression model

	All-cause mortality HR (95%CI) P-value	Cardiovascular mortality HR (95%CI) P-value	Cardio-cerebrovascular mortality HR (95%CI) P-value
Model I
One line	1.204 (1.077,1.345)0.0011	1.218 (0.987,1.503) 0.0657	1.163 (0.955, 1.417) 0.1340
Model II
Inflection value	18.284	18.297	18.308
< threshold value	0.851 (0.691, 1.047) 0.1274	0.926 (0.640,1.340) 0.6846	0.942 (0.657, 1.349) 0.7426
≥ threshold value	1.418 (1.229,1.635) < 0.0001	1.389 (1.066,1.810) 0.0150	1.288 (1.001, 1.658) 0.0494
P for log-likelihood ratio test	< 0.001	0.132	0.223

CI Confidence interval, HR Hazard ratio, SII (Platelet count × Neutrophils)/lymphocytes
SII was log2-transformed to fit the Cox regression model
Analysis was adjusted for age, gender, ethnicity, education, marital status, smoker, drinker, DM, hypertension, HF, CHD, stroke, cancer, BMI, hemoglobin, glycohemoglobin, platelets, uric acid, blood urea nitrogen, creatinine, cholesterol, glucose, LDL-C, HDL-C, triglyceride, albumin

ISSN: 2047-783X