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Table 1 Baseline characteristics of the study population stratified by tertiles of SII value

From: Systemic immune-inflammation index (SII) and the risk of all-cause, cardiovascular, and cardio-cerebrovascular mortality in the general population

Variable

Total (n = 26,855)

SII

P value

< 391,809.52

n = 8951

391,809.52–611,840 

n = 8951

> 611,840

n = 8953

SII

571,361.23 ± 348,108.33

292,056.57 ± 71,128.54

493,189.16 ± 62,910.48

912,502.63 ± 394,147.47

 < 0.001

Age, years

45.674 ± 17.238

45.059 ± 17.303

45.604 ± 16.704

46.319 ± 17.694

 < 0.001

Male (%)

48.268

53.637

48.776

42.741

 < 0.001

Ethnicity (%)

    

 < 0.001

 Non-Hispanic white

69.179

63.070

71.043

72.940

 Non-Hispanic black

10.879

16.362

9.121

7.590

 Mexican American

8.246

8.289

8.131

8.323

 Other race

11.697

12.279

11.704

11.147

Education (%)

    

 < 0.001

 < High school

16.964

18.083

15.715

17.215

 High school

22.828

20.964

23.272

24.105

 > High school

56.628

56.871

57.728

55.263

 Other

3.580

4.083

3.285

3.417

 Body mass index, kg/m2

28.471 ± 6.599

27.701 ± 5.976

28.521 ± 6.401

29.137 ± 7.246

 < 0.001

Marital status (%)

    

 < 0.001

 Never married

20.712

20.337

20.266

21.524

 Married

61.746

63.095

63.071

59.118

 Widowed

15.329

13.612

14.800

17.476

 Other

2.212

2.956

1.863

1.882

Drinker (%)

11.339

11.076

10.325

12.633

 < 0.001

Smoker (%)

45.260

42.896

44.575

48.172

 < 0.001

Diabetes mellitus (%)

8.190

7.690

7.540

9.329

 < 0.001

Hypertension (%)

29.719

27.280

29.620

32.093

 < 0.001

Heart failure (%)

2.323

2.124

1.819

3.029

 < 0.001

Coronary heart disease (%)

3.255

3.378

2.807

3.604

 < 0.001

Stroke (%)

2.637

2.311

2.526

3.055

 < 0.001

Cancer (%)

8.905

7.756

8.727

10.159

 < 0.001

Hemoglobin, g/dL

14.320 ± 1.500

14.340 ± 1.428

14.410 ± 1.470

14.208 ± 1.587

 < 0.001

Platelets, 103/μL

254.704 ± 66.015

217.850 ± 50.711

252.425 ± 53.501

291.398 ± 70.382

 < 0.001

Lymphocyte, 103/μL

2.118 ± 1.018

2.382 ± 1.514

2.118 ± 0.644

1.872 ± 0.619

 < 0.001

Neutrophil, 103/μL

4.338 ± 1.719

3.121 ± 0.975

4.155 ± 1.106

5.661 ± 1.857

 < 0.001

Triglyceride, mmol/L

1.679 ± 1.397

1.612 ± 1.323

1.711 ± 1.486

1.708 ± 1.366

 < 0.001

Blood urea nitrogen, mmol/L

4.641 ± 1.901

4.640 ± 1.739

4.653 ± 1.797

4.631 ± 2.136

0.728

Cholesterol, mmol/L

5.063 ± 1.063

4.975 ± 1.065

5.109 ± 1.046

5.095 ± 1.073

 < 0.001

Uric acid, μ mol/L

321.411 ± 83.162

321.776 ± 81.840

321.234 ± 81.974

321.255 ± 85.568

0.888

Creatinine, μ mol/L

78.541 ± 31.553

79.495 ± 31.037

78.001 ± 25.546

78.213 ± 37.142

0.003

LDL cholesterol, mmol/L

2.972 ± 0.905

2.904 ± 0.885

3.035 ± 0.906

2.979 ± 0.919

 < 0.001

HDL cholesterol, mmol/L

1.369 ± 0.407

1.371 ± 0.409

1.362 ± 0.400

1.375 ± 0.410

0.148

Albumin, g/L

42.789 ± 3.354

43.119 ± 3.118

43.013 ± 3.135

42.250 ± 3.700

 < 0.001

Glycohemoglobin

5.554 ± 0.891

5.544 ± 0.876

5.544 ± 0.883

5.573 ± 0.911

0.04268

All-cause mortality (%)

7.425

5.897

6.460

9.847

 < 0.001

Cardiovascular mortality (%)

1.210

0.908

1.136

1.568

 < 0.001

Cardio-cerebrovascular mortality (%)

1.459

1.100

1.371

1.885

 < 0.001

  1. Mean ± SD for: SII, age, body mass index, hemoglobin, albumin, cholesterol, triglycerides,uric acid, Blood urea nitrogen, creatinine, glycohemoglobin, HDL cholesterol, LDL cholesterol, Platelets, Lymphocyte, Neutrophil. P value was calculated by weighted linear regression model
  2. % for: gender, race, educational level, marital status, smokers, drinkers, hypertention,diabetes mellitus,coronary heart disease,stroke,cancer,congestive heart failure. P value was calculated by weighted chi-square test
  3. HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, SII: (Platelet count × Neutrophils)/lymphocytes
  4. Values are mean ± standardized deviation or number (%)
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European Journal of Medical Research

ISSN: 2047-783X

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