Fig. 3From: Both extracellular vesicles from helicobacter pylori-infected cells and helicobacter pylori outer membrane vesicles are involved in gastric/extragastric diseasesRole of H. pylori-OMVs in gastric and extragastric diseases. A H.pylori-derived OMVs may contribute to the inflammation of gastric epithelial cells through the induction of IL-8 production by NF-kappaB activation. B H. pylori derived gamma-glutamyl transpeptidase(GGT) induces the production of ROS and then promotes cell apoptosis; In addition, by inhibiting T-cell mediated immunity and dendritic cell differentiation, GGT could induce cell cycle arrest via the nuclear response and immune tolerance. C In addition, H.pylori-derived OMV upregulates the expression of hematopoietic stem cell activators and fibrosis markers in exosomes secreted by hepatocytes. Further activation of hepatic stellate cells (ahsc) promotes the progression of liver fibrosisBack to article page