The association of diastolic arterial pressure and heart rate with mortality in septic shock: a retrospective cohort study

Table 1 Effects of exposure to tachycardia and low DAP on 28-day mortality in patient with septic shock

	Exposure to tachycardia (HR ≥ 100 bpm)			Exposure to low DAP (DAP ≤ 40 mmHg)
	HR	95%CI	P value	HR	95%CI	P value
Baseline variables
Age, years	1.02	(1.01–1.03)	< 0.001	1.01	(1.01–1.02)	< 0.001
Male	0.81	(0.69–0.94)	0.004	0.85	(0.73–0.98)	0.026
BMI, kg/m²	0.99	(0.98–1.00)	0.075	0.99	(0.98–1.00)	0.097
CCU	0.33	(0.28–0.40)	< 0.001	0.32	(0.27–0.38)	< 0.001
OASIS	1.02	(1.01–1.03)	< 0.001	1.02	(1.02–1.03)	< 0.001
SOFA	1.09	(1.06–1.11)	< 0.001	1.08	(1.05–1.11)	< 0.001
CCI	1.10	(1.06–1.13)	< 0.001	1.09	(1.06–1.12)	< 0.001
Lactate, mmol/l	1.11	(1.09–1.13)	< 0.001	1.11	(1.09–1.13)	< 0.001
Time-dependent variables
Receiving IMV	1.24	(1.01–1.52)	0.034	1.24	(1.01–1.52)	0.032
Receiving CRRT	1.95	(1.52–2.50)	< 0.001	1.81	(1.41–2.32)	< 0.001
Use of vasopressors	3.20	(2.66–3.87)	< 0.001	3.15	(2.61–3.80)	< 0.001
Tachycardia (≥ 100bmp)	1.37	(1.10–1.70)	< 0.001
Low DAP (≤ 40 mmHg)				1.53	(1.31–1.79)	< 0.001

HR hazard ratio, CI confidence interval, BMI body mass index, OASIS Oxford Acute Severity of Illness Score, SOFA sequential organ failure assessment, CCI Charlson Comorbidity Index, CRRT continuous renal replacement therapy, IMV invasive mechanical ventilation, CCU Cardiac Care Unit, TWA time-weighted average, DAP diastolic arterial pressure, HR heart rate, bpm beats/breaths per minute

ISSN: 2047-783X