Fig. 4

Identification of DCGs. Genes for which the clustering coefficient increased by over 0.1 in the AMI group in both discovery cohort and validation cohort, are revealed as DCGs (A). Gene expression profile of DCGs shows a stable increase in the AMI group in both cohorts (B). The connections among DCGs in the AMI group are denser (C) and the average degrees of DCGs in AMI group are higher (D) compared to the control group in both cohorts. Networks are presented under threshold 0.5 and 0.7. Darker lines represent connections under threshold 0.7; lighter line represents connections under threshold 0.5. Degrees are presented as mean  ±  SEM. DCGs differential connectivity genes