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Fig. 3 | European Journal of Medical Research

Fig. 3

From: Co-existence of Alport syndrome and C3 glomerulonephritis in a proband with family history

Fig. 3

Functional characterization of the CFHR5 p.Val170Met variant. a Alignment of the CFHR5 protein in different species shows the conservation of the V170 residue. The concerned amino acids are boxed. b Generated models show the discrimination of local intramolecular hydrogen-bonding interactions between Val170 and Met170 by MOE. Hydrogen bonds are shown with a fluorescent green dotted line representation. c Structure of CFHR5 in complex with the ligand C3b-β chain (C3β) were generated with the DS 3.0. CFHR5 is denoted by pink, C3β (residues 1–642, PDB 2WII) is shown in turquoise. The binding regions of the CFHR5/C3β complex are presented in yellow. The Val residue 170 of CFHR5 is highlighted with a CPK model

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