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Table 1 Demographic characteristics, underlying diseases, clinical and laboratory findings, and outcomes

From: Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial

 

Group

p

Case (n = 30)

Control (n = 30)

Age (year), mean (SD)

57.53 (18.27)

61 (15.90)

0.436

Sex, n (%)

 Female

15 (50.00%)

15 (50.00%)

> 0.9

 Male

15 (50.00%)

15 (50.00%)

Hypertension, n (%)

15 (50.00%)

10 (33.33%)

0.190

Diabetes mellitus, n (%)

12 (40.00%)

11 (36.67%)

0.791

Ischemic heart disease, n (%)

4 (13.33%)

7 (23.33%)

0.506

COPD, n (%)

3 (10.00%)

3 (10.00%)

> 0.9

Thyroid disease, n (%)

2 (6.67%)

3 (10.00%)

> 0.9

Fever, n (%)

7 (23.33%)

19 (63.33%)

0.002

Chill, n (%)

7 (23.33%)

9 (30.00%)

0.559

Dyspnea, n (%)

25 (83.33%)

21 (70.00%)

0.222

Myalgia, n (%)

4 (13.33%)

18 (60.00%)

< 0.001

Weakness, n (%)

2 (6.67%)

4 (13.33%)

0.671

Cough, n (%)

26 (86.67%)

23 (76.67%)

0.506

Sputum, n (%)

1 (3.33%)

4 (13.33%)

0.353

Headache, n (%)

3 (10.00%)

8 (26.67%)

0.181

Vomit, n (%)

4 (13.33%)

2 (6.67%)

0.671

Chest pain, n (%)

2 (6.67%)

5 (16.67%)

0.424

Hemoptysis, n (%)

0 (0%)

3 (10.00%)

0.237

Positive PCR, n (%)

22 (73.33%)

30 (100.00%)

> 0.9

Negative PCR, n (%)

8 (26.66%)

0 (00.00%)

WBC count (× 103/µl), mean (SD)

6.60 (3.65)

6.43 (3.69)

0.861

Lymphocyte (count/µl), mean (SD)

1082.68 (582.17)

1042.52 (590.81)

0.792

HB (g/dl), mean (SD)

13.35 (2.29)

12.65 (2.06)

0.218

PLT (× 103/µl), mean (SD)

194.20 (83.75)

203.30 (74.64)

0.658

AST (u/l), mean (SD)

35.93 (15.92)

33.93 (13.96)

0.607

ALT (u/l), mean (SD)

31.73 (8.57)

34.43 (9.69)

0.258

LDH (u/l), mean (SD)

619.20 (212.10)

599.67 (197.93)

0.714

CRP (mg/dl), mean (SD)

41.30 (28.86)

58.13 (52.80)

0.132

ESR (mm/hour), mean (SD)

60.00 (30.71)

66.03 (30.45)

0.448

Body temperature upon admission(°C), mean (SD)

37.03 (0.80)

37.93 (0.92)

< 0.001

3rd day temperature (°C), mean (SD)

36.73 (0.36)

37.24 (0.69)

0.001

Body temperature at discharge (°C), mean (SD)

36.76 (0.47)

36.85 (0.46)

0.454

SPO2 upon admission (%), median (IQR)

86.0 (82.0–88.0)

87.5 (85.0–88.0)

0.148

3rd day SPO2 (%), median (IQR)

90.5 (88.0–92.0)

88.0 (80.0–91.0)

0.014

SPO2 at discharge (%), median (IQR)

93.5 (91.0–95.0)

92.5 (92.0–94.0)

0.406

ICU length of stay (day), median (IQR)

5.50 (5.0–10.0)

5.0 (5.0–7.0)

0.381

Hospital length of stay (day), median (IQR)

8.50 (7.0–12.0)

6.50(4.0–12.0)

0.028

Expire, n (%)

3 (10.00%)

3 (10.00%)

> 0.9

Intubation, n (%)

5 (16.67%)

4 (13.33%)

> 0.9

Corticosteroid treatment, n (%)

8 (26.66%)

7 (23.33%)

0.77

Severity score, mean (/10) (SD)

3.57 (1.357)

3.40 (1.476)

0.651

  1. SD standard deviation, n count, IQR interquartile range (25–75%), COPD chronic obstructive pulmonary disease, WBC white blood cell, HB hemoglobin, PLT platelet, AST aspartate transaminase, ALT alanine transaminase, LDH lactate dehydrogenase, CRP C-reactive protein, ESR erythrocyte sedimentation rate, SPO2 oxygen saturation, ICU intensive care unit, PCR polymerase chain reaction