Fig. 5
From: Clinical significance of dysregulation of miR-381 in pediatric acute myeloid leukemia
HMGB1 is a direct target of miR-381. a Bioinformatics analyze showed that miR-381 contains binding sites for HMGB1. b Transfection of miR-381 mimic decreased the luciferase activity in cells transfected with wild type 3′-UTR of HMGB1, whereas the luciferase activity was increased by miR-381 inhibitor transfection significantly. However, mutation in the miR-381 binding sites in the 3′-UTR of HMGB1 abolished the effect on the luciferase activity. *** P < 0.001, compared with control group