Fig. 4

Inhibition of eNOS abolished the regulation of microcirculation and hypoxia of LIPC against CI-AKI. L-NAME significantly decreased renal medullary blood flow (a), but not cortical blood flow (b) in LIPC + CM. Representative photomicrographs of kidney sections of CI-AKI with Hypoxyprobe staining (c). L-NAME significantly increased score of Hypoxyprobe staining in 15 and 30 min in CM + LIPC (d). Original magnification ×200. *P < 0.05, **P < 0.01, ^#P < 0.01; n = 6 each. The values shown are the mean ± SD