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Table 1 Pharmacokinetics of echinocandins for the treatment of Candida infections

From: Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis - review of the literature

Parameter

anidulafungin

caspofungin

micafungin

Mode of administration

IV

IV

IV

Dose linearity

+

+

+

Oral availability [%]

n/a

n/a

n/a

Plasma protein binding [%]

99

97

99

Volume of distribution [L]

30-50

n/a

18

Elimination half-life [h]

24

9-11

10-17

Route of elimination

D,

D/M

M

 

F

U > F

F > U

  1. E = excretion unchanged; M = drug is metabolised; D = drug is degraded; U = urine; F = faeces