Table 7 Calculated antibiotic therapy with necrotising pancreatitis and secondary cholangitis.
Diagnosis | Likely organism | Initial therapy | Level of evidence | Strength of recommendation |
|---|---|---|---|---|
Necrotizing pancreatitis without infection | none | none | 1 | A |
Necrotizing pancreatitis with infected necrosis | Enterobacteriaceae | Imipenem-Cilastatin | 1 | A |
| Â | Enterococci | Meropenem | 1 | A |
| Â | Staphylococci | Ertapenem# | 1 | A |
| Â | Â | Acylaminopenicillin/BLI | 1 | A |
| Â | Â | Ciprofloxacin* + Met. | 1 | B |
| Â | Â | Levofloxacin* + Met. | 1 | B |
| Â | Â | Cephalosporin group 2 + Metronidazole | 1 | B |
| Â | MRSA VRE ESBL | see Table 5 | Â | Â |
| Â | Candida spp. | see Table 6 | Â | Â |
Secondary cholangitis | Enterobacteriaceae | Aminopenicillin/BLI | 1 | A |
| Â | Enterococci | Ciprofloxacin* + Met. | 1 | B |
| Â | Anaerobes | Levofloxacin* + Met. | 1 | B |
| Â | Â | Acylaminopenicillin/BLI | 1 | A |
| Â | Â | Ceftriaxon | 1 | B |
| Â | Â | Imipenem-Cilastatin | 1 | A |
| Â | Â | Meropenem | 1 | A |
| Â | Â | Ertapenem# | 1 | A |
| Â | Â | Cefepime | 3 | B |
| Â | Pseudomonas spp. | see Table 5 | Â | Â |