From: The treatment of chronic hepatitis C virus infection in HIV co-infection
Diagnosis of hepatitis C |
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HCV-Ab (positive 1-5 months after infection, may rarely be lost with immunosuppression) |
HCV-RNA levelsa (in particular predicts response to treatment) |
Status of liver damage |
Grading of fibrosis (e. g. FibroScan, liver biopsy, serum fibrosis markersb) |
Hepatic synthetic function (e. g. coagulation, albumin, CHE) |
Ultrasound and AFP every 6 months in cirrhotics (gastroscopy upon diagnosis of cirrhosis and every 1-2 years thereafter) |
Before HCV treatment |
HCV genotype and serum HCV-RNA |
Autoantibodies (ANA, LKM1)c |
TSH, thyroid autoantibodies |
Monitoring of HCV treatment |
Differential blood count and liver enzymes every 2-4 weeks |
HCV-RNA at week 4 (to evaluate rapid virological response), and weeks 12, 24, and 48 (72 if applicable) and 24 weeks after stopping HCV therapy |
CD4-count every 12 weeks |
TSH every 12 weeks |